Maurizio Sarri’s Chelsea maintained their winning start to the Premier League season with victory over Newcastle United in a match featuring three goals in 11 second-half minutes.

Eden Hazard, on his first start this season for the Blues, netted from the penalty spot in the 76th minute before substitute Joselu levelled with a brilliant header at St James’ Park.

But, having been resolute in defence for the majority of the game, Newcastle failed to clear their lines and Marcos Alonso’s shot took a deflection off DeAndre Yedlin.

Chelsea dominated the game with 82% possession and Pedro, Cesar Azpilicueta and Alvaro Morata missed chances.

Antonio Rudiger rattled the crossbar in the 70th minute but Newcastle contained the pressure until Fabian Schar tripped Alonso in the box.

Chelsea’s third win in as many matches moved them level on points with Liverpool and Watford at the top of the table, while Rafael Benitez’s Newcastle have only one point.

All defence, no attack for Newcastle

Benitez was forced to make six changes to the side that drew with Cardiff last weekend, with captain Jamaal Lascelles and midfielder Jonjo Shelvey among those absent through injury.

The starting XI, featuring three debutants, held their own as a five-man defence for much of the game but never looked a threat up front.

Salamon Rondon, making his first start since arriving from West Brom, headed wide in the first half, while Joselu’s 83rd-minute header was one of only two shots on target for the hosts.

The German’s goal caused controversy, with Chelsea substitute Olivier Giroud claiming he was elbowed off the ball by Yedlin in the build-up.

It did not matter as Yedlin’s own goal sent the Magpies to their second defeat of the season.

First start, first goal, first-class Hazard

After a World Cup summer and reports of interest from Real Madrid, Belgium forward Hazard had to settle for two appearances from the bench before this match.

He received a less than friendly welcome by the hosts on his return to the starting XI. In the first minute, he was caught on the back of the ankle by the studs of Matt Ritchie, and was then clattered on the right leg by Mohamed Diame.

Off the ball Hazard moved gingerly at times, but for the most part he was the driving force for Chelsea, whose dogged and unrelenting attack finally came to fruition in the latter stages.

Hazard’s well-taken penalty was his 70th Premier League goal for Chelsea, which puts him behind only Frank Lampard (147) and Didier Drogba (104) in the club record books.

Man of the match – Eden Hazard

Jorginho completes more passes than Newcastle – match stats

• Jorginho completed 158 passes out of a possible 173, more than the whole Newcastle side combined (131).
• Victory was Chelsea’s first in the Premier League at St James’ Park since December 2011, having drawn one and lost four of their previous five matches.
• Maurizio Sarri is the fifth Chelsea manager to win his opening three Premier League games after Antonio Conte, Carlo Ancelotti, Guus Hiddink and Jose Mourinho.
• All six of Joselu’s six Premier League goals for Newcastle have come at St James’ Park.

What they said

Newcastle manager Rafael Benitez: “Both the penalty and foul leading up to it were very doubtful.

“We had six players out. Jonjo Shelvey was not there for us today but we did a good job and it was a pity. We showed last year that we finished 10th and didn’t make mistakes in terms of decisions.

“We don’t have any issues. We have some injuries and it’s something we have to manage.”

Chelsea boss Maurizio Sarri: “I have never seen a Rafa Benitez side play with five defenders. It is very difficult to play here for every team – not only us.

“We were a bit unlucky when they scored to make it 1-1.

“Eden (Hazard) has played very well but maybe it was better if he played for only 75-80 minutes, but (Mateo) Kovacic asked me to be replaced so it was not possible.”

What’s next?

Chelsea host Bournemouth, who are also unbeaten this season, at Stamford Bridge on Saturday (15:00 BST).

Newcastle travel to Nottingham Forest in the EFL second round on Wednesday (19:45), before a trip to champions Manchester City in the league on Saturday (17:30).

ANNAPOLIS, Md. — He will overlook the Severn River, surrounded by birds chirping from the large maple and sycamore trees that flank his final resting place.

At the bottom of a green hill speckled by hundreds of gravesites for Naval lieutenants, midshipmen, commanders and admirals — some of whose service concluded centuries ago — Sen. John McCain will have a front-row view of sailboats and ships passing on the river while a new generation of naval officers play soccer on Sherman Field at the U.S. Naval Academy.

It’s the place where his career began. It’s where he wanted it to end. 

McCain died Saturday evening after a year-long battle with a rare form of brain cancer. He was 81. He will be buried at the U.S. Naval Academy Cemetery.

More: Sen. John McCain, American ‘maverick’ and political giant, dies at 81

More: John McCain’s top quotes through the years

His legacy here in Annapolis isn’t focused on his six terms as an Arizona senator or his two presidential bids. In the place where he will be put to rest, McCain is thought of as a national treasure, a respected hero and one of the city’s most prized naval officers in recent memory. 

“It’s not necessarily political,” Amy Bleidon, a 1998 Navy Academy graduate, said of McCain’s legacy.

Rather, she added, he will be remembered in the community for both his “lifelong service” to the country and as a leader who exemplified the respect and character the Navy instills in its officers. 

“That lifelong devotion I think is what made him so well thought of by everyone,” she added.

Bleidon, who jogs through the large, colonial-style campus every weekend, says this is the place where so many, including herself, “grew up” and matured. 

That’s what it seems the academy did for McCain, who was a well-known rebel when he attended.

The future senator stuck his nose up at the strict rules of the school, drawing demerits, but just as many friends who gravitated to his quick wit and adventurous ways. His rebel attitude would later inspire his “maverick” persona.

He was one of the most popular midshipmen in his 1958 class, becoming a legend of sorts because of his no-rules attitude. 

It was at the academy where McCain met who would become a lifelong friend, Charles “Chuck” Larson.

The pair were known as the “odd couple.” McCain was nicknamed “McNasty” for his no-rules attitude that in-turn left him near the bottom of his graduating class, while Larson was a high-achieving naval student who scored good grades. McCain has said he always looked up to his friend. 

Larson grew up in Nebraska and rose from an aviator, flying missions in Vietnam, to naval aide to President Richard Nixon. He twice served as the superintendent of the U.S. Naval Academy. 

McCain, meanwhile, served during the Vietnam War, surviving at least two near-death encounters, including five years as a prisoner of war, before his transition into politics. 

McCain and Larson remained close friends over their careers and will stay close even in death. 

Larson died in 2014 at age 77 and was buried at the Naval Academy Cemetery in Annapolis. Before his death, McCain picked a burial plot right next to his, both at the edge of a hill overlooking the Severn River.

McCain’s resting place was marked Saturday afternoon with two wooden stakes, one marked with the location and McCain’s name. Parked in the middle of the plot was an orange cone.

A Navy hat and American flag sat nearby at Larson’s grave. 

“It’s really only fitting,” said Navy lieutenant Raymond Dennis, gazing out at the cemetery. “He’s so loved here and celebrated. I mean, he was a prisoner of war, tortured for five years, then continued to serve our nation. This is his home and where he should spend eternity.”

Annapolis is a Navy city. The downtown streets are sprinkled with officers in their white uniforms. And McCain seems to be taught almost like a school lesson. His biography is memorized like trivia by many, including Dennis. 

As his dog, Maverick, dried off from a swim in the Severn River, Dennis said many young naval officers jog through the cemetery as almost a guide through history, remembering the leaders of yesterday. 

“It’s a way for them to connect with the past,” he said. “I’m sure everyone here will want to maintain that closeness with McCain and his legacy.”

That legacy and his code of honor is what so many at his alma mater say defined him over any headline or any political maneuvering. 

It’s what made him likable to nearly everyone, no matter political affiliation or beliefs. 

“Everyone can learn from him, that sense of resilience and decency and respect,” Dennis added. “It’s very sad. I think his death will cause a void.” 

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When Facebook started off it was essentially an online yearbook based entirely on where you went to college — you could only log in if you had a .edu email address.

In the intervening 14 years the social media platform has changed the digital landscape (to put it mildly), acquired other networks like Instagram, and moved far from its university-based networks. But now Instagram is considering a feature very similar to Facebook’s early days.

A new feature reportedly being tested allows student ‘grammers to join networks or special communities based on their school affiliation.

A CNBC report on Friday showed invites asking students to join university community lists and “connect with other students.” It’s supposed to be a tool for current students, so alumni groups can stick to LinkedIn and Facebook.

If you do join, you can add your university and expected graduation year to your profile — very reminiscent of early Facebook. Now it’s only optional to include education information on your Facebook profile.

We reached out to Instagram for more information about the new school-focused feature.

Other than both launching at the start of the school year, the new Instagram feature is nothing like the new Tinder U dating app, which allows college students to search for matches within a geo-located area as long as they have active .edu email addresses.

A senior Vatican official called on Pope Francis to resign, accusing the pontiff of failing to act sooner on sexual abuse allegations against former cardinal Theodore McCarrick.

In an 11-page statement, Archbishop Carlo Maria Vigano said sanctions imposed on McCarrick by Pope Benedict XVI over sexual misconduct were lifted under Francis, despite reports about his “gravely immoral behaviour with seminarians and priests”.

Vigano said he informed Francis in person in 2013 of the sanctions and how McCarrick, ex-archbishop of Washington, DC, “corrupted generations of seminarians and priests”.

Pope Francis “continued to cover” for McCarrick despite the sanctions and even made him “his trusted counselor”, Vigano alleged.

“In this extremely dramatic moment for the universal church, he must acknowledge his mistakes and, in keeping with the proclaimed principle of zero tolerance, Pope Francis must be the first to set a good example for cardinals and bishops who covered up McCarrick’s abuses and resign along with all of them,” he said.

The Vatican had no immediate comment on the allegations.

‘Betrayal’

Vigano, 77, a conservative whose hard-line anti-gay views are well known, has long been seen as a critic of Pope Francis, who is viewed as more moderate. 

His letter also contained a lengthy diatribe about homosexuality and liberals in the Catholic Church.

Vigano’s criticism came as Pope Francis made a two-day visit to Ireland, where he addressed sex abuse scandals and “begged for God’s forgiveness” for the “betrayal” by the church.

On Sunday, Pope Francis told tens of thousands of people gathered in Dublin: “None of us can fail to be moved by the stories of young people who suffered abuse, were robbed of their innocence and left scarred.”

Francis met privately on Saturday with eight victims of clerical, religious and institutional abuse, saying he would seek greater commitment to eliminate the “scourge”.

 

Vigano’s statement, first published in the conservative American publication the National Catholic Register, also claimed several Vatican officials knew for years about the allegations against McCarrick.

An investigation was launched after a man claimed he was sexually abused by McCarrick when he was 11 years old. Similar allegations were made against McCarrick by other men who were seminarians studying for the priesthood.

In July, McCarrick resigned as cardinal after he was removed from official duties in June.

A recent US grand jury report into sexual misconduct and coverups found 300 priests abused more than 1,000 children over 70 years in the state of Pennsylvania while senior church officials took steps to conceal it.

Vigano himself has had his own problems with allegations of trying to hide the truth.

The coverup accusation, which Vigano denied, concerned accusations he tried to quash an investigation into a former archbishop accused of misconduct.

SOURCE: Al Jazeera and news agencies

Everton defender Michael Keane suffered a hairline fracture of his skull during Saturday’s draw at Bournemouth.

The England centre-back clashed heads with team-mate Idrissa Gueye in injury time and was taken to hospital after six minutes of treatment on the pitch.

“Michael Keane has sustained a small hairline fracture of the skull but suffered no other complications,” said an Everton statement.

Keane, 25, said he must avoid head contact for three to four weeks.

The defender had earlier scored to put the Toffees 2-0 up in their Premier League match at the Vitality Stadium, before the Cherries fought back to earn a point.

“I will be back with my team and back on the pitch as soon as I can,” Keane posted on social media on Sunday.

“I’m OK but suffered a small hairline fracture of the skull, which will heal itself.”

Kristen Hanson, Opinion contributor
Published 6:00 a.m. ET Aug. 26, 2018

The so-called “death with dignity” movement gives in to despair and preys on terminally ill patients when they are most vulnerable.

On Dec. 30, 2017, as snowflakes fell outside his window, my husband and the love of my life, J.J. Hanson, took his last breath. He was 36 years old. I was with him, holding our two young sons in my arms. We had known the day would come — J.J. had been living with terminal brain cancer for three and a half years. But that was more than three years longer than his doctors had expected.

Learning you or a loved one has a terminal illness is devastating and scary. In our case it was also a shock. J.J. was a Marine Corps veteran of Iraq, a new father, and he had a job he loved. We were living the American dream and thought we had a long future ahead of us, until we learned J.J. had stage 4 glioblastoma multiforme, one of the most aggressive and deadliest forms of brain cancer.

Living through that kind of illness day-to-day is a constant struggle that requires immense courage and great strength. J.J. had both. But even then, he — like many people who receive terminal prognoses — went through dark periods of depression.

Struggling against despair

Our struggle was taking place around the same time Brittany Maynard’s story made headlines across the country. Maynard suffered from the same cancer as J.J. and was roughly the same age, but she famously decided to end her own life through assisted suicide in Oregon and to advocate its legalization in her home state of California.

I didn’t know it then, but J.J. later admitted that during his illness, he sometimes felt such despair that he may have taken a lethal prescription had it been legal in New York, where we lived, and if he had it in his nightstand during his darkest days. He was tempted to believe that ending his life would relieve the burden on his caretakers and allow him to bypass the experience of illness-induced disability that the disease would otherwise cause.

More: Am I the only mom who secretly wishes my kid won’t play football?

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Many people who consider or go through with assisted suicide have similar fears. Data from Oregon — where assisted suicide first became legal — show the main end-of-life concerns that people considering assisted suicide report relate to existential suffering, such as becoming burdensome to caretakers and facing disability. In fact, “inadequate pain control” or concern of physical pain isn’t even in the top five reported reasons.

There’s no telling what would have happened to J.J. and our family if lethal pills were available to him during that dark period. What we do know is that, as J.J. said, the support and hope of loved ones carried him past that difficult time and toward a different conclusion than the one Maynard reached. 

Enduring in hope

Hope inspired us to try standard and experimental treatments to combat J.J.’s cancer. Those treatments extended his life beyond the initial four-month prognosis to three and a half years. If we had relied on the initial prognosis, given in to the depression and given up on hope, we would have missed out on so very much. Our oldest son, James, would never have gotten to know his father; our youngest son, Lucas, would never have been born.

Getting through his darkest moments and the temptation to despair made J.J. realize that assisted suicide presents a very real risk for terminally ill patients like him. J.J. and I resolved to fight efforts to legalize assisted suicide, laws that prey on terminally ill patients when they are most vulnerable. Assisted suicide is currently legal in seven states and the District of Columbia. This is a tragedy, and one we can prevent.

J.J. served as president of the Patients Rights Action Fund, an organization that works on behalf of patients to oppose legalizing assisted suicide. We dedicated the last years of J.J.’s life to this because we recognized the “death with dignity” movement for what it is: a well-funded re-branding of euthanasia offering nothing but a message of hopelessness.

If our experience taught us anything, it is to hold on to hope for yourself and for others around you, especially in the face of life-threatening illness. You could be improving their lives, as well as your own.

Kristen Hanson is a community relations advocate with the Patients Rights Action Fund.

 

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Image: Jon LeMay/ABC via Getty Images

When you think Tim McGraw, you probably think Taylor Swift too. 

Her first single, “Tim McGraw,” had a big moment on Saturday night thanks to a special appearance by McGraw himself, along with Faith Hill. The country music power couple joined Swift in Nashville — where it all began for her — and fans went absolutely nuts. 

Swift sang the first half of the love song with Hill, before introducing “the actual Tim McGraw” to finish it off in front of the sold out crowd.

Swift first wrote the song in high school, and since then has performed other material with McGraw and Hill over the years as her career has taken off. She even opened for the couple on tour in 2007, which made this Nashville moment a special one. 

The significance of it all sunk in with fans during and after the show, and many tweeted excitedly about the performance. 

Until the next time this magical moment happens, we’ll just be watching this classic on loop. 

The tourism industry in India’s southern Kerala state has been hit hard as the state reels from the worst flooding in over a century that has left more than 300 people dead.

Incessant rain since August 8 caused the worst floods and triggered landslides, with the death toll reaching 445 with the discovery of 28 more bodies on Sunday.

Tourism accounts for 12 percent of Kerala’s economy and the flooding that forced tourists to cancel their trips, has brought loss to the hospitality business owners in the state. 

“I think about 75 to 80 percent of cancellations have happened during that period,” Ellias Najeeb, president of the Confederation of Kerala Tourism Industry, told Al Jazeera.

“And all the tourists that were staying in the affected areas have gone back.”

The outlook does not look great either. A similar percentage of September bookings have been cancelled. 

The flood damaged roads, rail-lines and airports, making it hard for travelers to reach their destination.

The biggest impact will reportedly be felt from October when the peak tourist season for Kerela begins.

Those in the industry expect a 20 to 25 percent drop for the season as a whole.

However, Kerala’s Tourism Minister, Kadakampally Surendran, is confident the visitors will return.

“Our industry is badly affected, it’s devasted. But I’m confident we will get our former glory back. It is going to take a lot of work,” said Surendran.

The rainfall during the June-September season was recorded as more than 40 percent higher than normal. That forced authorities to release water from dozens of full dams.

But even as the water receded, dozens of people are still missing and around a million are sheltering in thousands of makeshift relief camps, state officials said.

Watford v Crystal Palace, Fulham v Burnley & Newcastle United v Chelsea live – Live – BBC Sport

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It emerges from tissue cells in the brain itself, spreading like an interlocking network of tiny fingers with such speed that pinpointing treatment is chasing a moving target.

It stimulates the abnormal growth of blood vessels around itself to assure it is well fed. And even if the main body of cancerous tissue is removed and the patient is treated with radiation or chemotherapy, a few hard-to-reach cells multiply, divide and grow stronger.

Then the whole process starts again.

This is glioblastoma, the most aggressive of all tumors originating in the brain.

And though researchers have moved forward during the past decade in understanding this deadly brain tumor, the type that afflicts Sen. John McCain remains incredibly difficult to halt. 

Understanding improves, but progress is slow

There has been little progress in developing new U.S. Food and Drug Administration-approved drugs since McCain’s former U.S. Senate colleague, Ted Kennedy, succumbed to the same type of brain cancer in 2009. And it remains deadly: Half of patients with glioblastoma die within 15 months.

Nonetheless, doctors are constantly testing new drugs and drug combinations to slow the growth of these tumors after standard treatments of radiation and chemotherapy have failed.

“I think our understanding is better than it’s ever been,” said Dr. Nader Sanai, a neurosurgeon at Barrow Neurological Institute in Phoenix and director of its Brain Tumor Research Center. “Obviously, this (McCain’s) is a similar situation to Senator Kennedy’s. That was 10 years ago and the field has advanced, though in this day and age, it’s still difficult.”

Medical researchers are pressing ahead with clinical trials testing dozens of drugs, drug combinations and unique methods of delivering therapies to tumors. In Arizona alone, there are 13 clinical trials recruiting patients with glioblastoma, according to the federal government’s ClinicalTrials.gov website.

One of the foremost problems: Finding a workable drug that can reach the tumor. The brain is protected by a membrane called the blood-brain barrier that protects it and the central nervous system.

“Most experimental drugs are ineffective in reaching the area of the brain that you need to reach,” said Sanai. “The brain is designed to keep drugs out.”

Using the immune system to fight tumors

One emerging area, immunotherapy, includes therapies that prod the body’s immune system to attack the tumor. This type of therapy has been used to fight other types of cancer, and researchers are testing whether it would work in the brain.

A type of immunotherapy is chimeric antigen receptor (CAR) T-cells that are genetically engineered to attack glioblastoma. Duarte, Calif.-based City of Hope last December reported in the New England Journal of Medicine that doctors used this therapy on a 50-year-old man with glioblastoma.

The man’s brain cancer had returned six months after being halted by an initial round of surgery, radiation and the chemotherapy drug temozolomide. 

“When he came to us, he had many tumors on his brain,” said Dr. Behnam Badie, City of Hope’s chief of neurosurgery and director of its brain tumor program. “Survivability was really, really dim. You are talking weeks.”

Doctors injected genetically engineered CAR T-cells into the patient’s brain, and his tumors regressed for nearly eight months. However, tumors later spread and the patient died this spring.

City of Hope, which is affiliated with the Phoenix-based Translational Genomics Research Institute, or TGen, has enrolled about 20 patients in the study, Badie said.

“It’s not curative,” Badie said. But, he added, “We are definitely seeing changes in the biology and extending lives.”

‘Cautiously optimistic’ about ‘poliovirus’ study

Other approaches that have received widespread attention include Duke University’s “poliovirus” study that uses a modified version of the polio virus to enter glioblastoma and attack the cancerous cells from within. 

Duke’s first clinical trial enrolled 61 people with the brain tumor after initial radiation and chemotherapy failed. Of those, 20 percent are living at least two years and two people are living more than five years. 

Duke’s study team is “cautiously optimistic” about the phase one study’s results, considering half of all patients with glioblastomas that return after initial treatment die within eight months, said Dr. Henry Friedman, a neuro-oncologist and deputy director of Duke University’s Preston Robert Tisch Brain Tumor Center.

“Obviously, we are not going to jump up and down when we have an 80 percent failure rate,” Friedman said. 

Duke has launched a follow-up study of the poliovirus treatment combined with the chemotherapy drug lomustine.

‘Phase zero’ trials address barriers

Barrow Neurological Institute, meanwhile, has launched a “phase zero” study that aims to rapidly test drugs on patients whose brain cancer tumors have returned after standard treatment.

While conventional clinical trials study drugs over several years, Barrow’s program seeks to quickly test experimental drugs within months.

In this regimen, doctors give patients drugs hours or days before a surgery. When a tumor is removed, doctors analyze the genetic profile of the tumor and evaluate whether the drug penetrated cancerous tissue and slowed its growth.

Sanai said the phase zero trials seek to address two of the main barriers to developing new therapies: verifying that drugs have reached the tumor, and ensuring that the tumors have responded to the drugs. 

The latter is an obstacle in brain-cancer research because experimental drugs that are first tested and show promise in animals might not work in humans. Scientists often assume that a tumor should respond to a drug based on success in early tests in animals. But human brains, brain tumors and genetic signatures are far more complex than what scientists are able to study in animals, Sanai said.

Barrow has tested multiple drugs as part of its study, which has enrolled fewer than 100 patients.

“Currently, what you are hearing about most is immunotherapy,” Sanai said. “These trends come and go. In the end, the fundamental problems always boil down to those two issues” — drugs reaching the tumor, and the complexity of human tumors compared with animal tumors.

‘Just never give up’

A Valley-based foundation, the Ben and Catherine Ivy Foundation, has funded several brain-cancer research efforts at TGen and other research institutions. Catherine Ivy launched the foundation in 2005 after her husband, Ben Ivy, was diagnosed with glioblastoma and died four months later. 

Ivy said her foundation remains committed to supporting brain-cancer research efforts, including new diagnostic tools that can improve treatment. 

She said she was saddened by McCain’s diagnosis, though she also had some advice for the Arizona senator and his family.

“Just never give up,” Ivy said. “There’s a strong community of people working very hard to conquer this disease.”

READ MORE:

Sen. John McCain returning to Arizona to start cancer treatment on Monday

Sometimes the fight against cancer isn’t the fight we expect

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